Prostate Specific Antigen

I talked early on in my blog about PSA and the fact that it exists in milk.
PSA stands for prostate specific antigen. Its increase over time (PSA velocity) is used as a measureto be suspicious if a man has prostate cancer and, therefore , whether he needs a prostate needle biopsy. PSA has a more sinister function. When insulin-like growth factor-one (IGF-1) circulates in the blood stream, it is usually bound to a binding protein. When bound to a binding protein it is not free to wreak havoc by causing cancer. It is the free IGF-1 that is involved in the cancer causing process.PSA is also an enzyme and splits IGF-1 away form its binding protein. This raises free IGF-1 to wreak havoc . So you have PSA in the milk you drink and your tumor produces PSA which act to increase free IGF-1 which in turn makes the tumor grow faster and this produces more PSA and the cycle continues. The home work for today’s blog is:

Insulin-like growth factor binding proteins (IGFBPs) as potential physiologic substrates for human
Kallikreins hK2 and hK3.

Link is: http://www.ncbi.nlm.nih.gov/pubmed/11358513
I talked early on in my blog about PSA and the fact that it exists in milk.
PSA stands for prostate specific antigen. Its increase over time (PSA velocity) is used as a measure
to be suspicious if a man has prostate cancer and, therefore , whether he needs a prostate needle
biosy. PSA has a more sinister function. When insulin-like growth factor-one (IGF-1) circulates in
the blood stream, it is usually bound to a binding protein. When bound to a binding protein
it is not free to wreak havoc by causing cancer. It is the free IGF-1 that is involved in the cancer causing process.
PSA is also an enzyme and splits IGF-1 away form its binding protein. This raises free IGF-1 to
wreak havoc . So you have PSA in the milk you drink and your tumor produces PSA which
act to increase free IGF-1 which in turn makes the tumor grow faster and this produces more PSA
and the cycle continues. The home work for today’s blog is:

Insulin-like growth factor binding proteins (IGFBPs) as potential physiologic substrates for human
Kallikreins hK2 and hK3.

Link is: http://www.ncbi.nlm.nih.gov/pubmed/11358513

High Levels of Estrogens in Milk

We talked previouly about the estrogen receptor alpha which in our discussion is increased in both prostate cancer and breast cancer. Its stimulation by estrogens is implicated in development of these cancers. Dr. Lyndom Larcom of Clemson has already shown in the lab that estrogens markedly stimulate the growth of prostate cancer tissue. We know that women with estrogen sensitive breast cancer take Temoxifen to block the estrogen receptor alpha.

So should we be concerned about the high levels of estrogens in dairy? The answer is absolutely yes. Garcia-Pelaez and fellow researchers stated in a paper whose link will follow that they were concerned about the high levels of estrogens in dairy..

Title of paper: Technical note: Measurement of Total Estrone Content in Foods. Application to Dairy Products.-R.Bibb,M.D.

The verdict is in : Dairy Kills

Great Website:


http://knol.google.com/k/cancer-prevention#

Slow Death

I talked earlier about the two killers in dairy that accomplish the most harm in initiating malignancies of the prostate and breast. How is this accomplished? Almost everyone has heard of estrogen positive breast cancer. It turns out that for hormonally sensitive cancers such as those of the breast and prostate there are receptors or receivers of estrogen known as receptors alpha and beta.Generally, if you stimulate estrogen receptor alpha you can cause cancer and if you stimulate estrogen receptor beta you can decrease the chance of cancer. In a balanced situation or normal state you are likely to have equal numbers of alpha and beta receptors. During milk and dairy ingestion you are consuming high levels of estrogens and the growth facter IGF-1. This is a dangerous situation because this combination results in an increase of both the estrogen receptors alpha and IGF-1 which result in transformation of prostate and breast cancer tissue to become cancerous.As always, I will give you an important paper to read. Most of the scientific papers can be pulled up on Entrez Pub Med which is the scientific section of the library of Congress. The important paper for this post is: Estrogen action on the prostate gland: a critical mix of endocrine and paracrine signaling by Risbridger GP. et al. Journal of Molecular Endocrinology. 2007 Sep;39(3):183-188.

National Breast Cancer Coalition Fund

National Breast Cancer Coalition Fund

IGF-1 and Estrogens

I will now concntrate on the most likely candidates in dairy that cause cancer. They are estrogens and what is known as insulin-like growth factor one which is also known as IGF-1.Several researchers have looked at the correlation of serum IGF-1 levels and the incidence of breast and prostate cancer and have found a direct correlation between risks of prostate and pre-menopausal breast cancer with the higher levels of IGF-1. The articles are:

1. Shaneyfelt T. et al. Hormonal predictors of prostate cancer: a meta-analysis. Journal of Clinical Oncology.2000 Feb;18(4):847-53.at:
http://www.ncbi.nlm.nih.gov/sites/entrez
2.Hankinson SE. et al. Circulating concentrations of insulin-like growth factor-1 and risk of breast cancer. Lancet. 1998 May 9;351 (9113):1393-6. at:
http://www.ncbi.nlm.nih.gov/sites/entrez

Milk and Hormones

Hopefully you have read the papers that showed that dairy can cause prostate cancer in an appropriate animal model. Why would that be the case? It is known that prostate cancer, breast cancer, ovarian and endometrial cancers are sensitive to hormones. Why should we worry about dairy products. Milk is made by cows for their calves. Milk is a hormonal delivery system for these calves. Grosvenor and others showed that milk contains many bioactive hormones and proteins. Among the hormones in milk are estrogens, testosterone,insulin-like growth factor, progesterone and PSA. Grosvenor et al can be accessed at:

http://www.ncbi.nlm.nih.gov/pubmed8119234 and the title is:

Hormones and growth factors in milk. Please read this extract or the whole paper can be downloaded for free and we will next talk about what these hormones can do to you.-R.Bibb, M.D.

Blog two

I will make it easy and post the links for the papers mentioned in the first blog.

1.http://www.jstage.jst.go.jp/article/jhs/52/4/52_419/_article

2.http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=872132&dopt=AbstractPlus


Once these articles have been read, I will then start the educational process. Let me emphasize that these articles confirm development of prostate cancer in an animal model that is much like the human prostate gland.-R.Bibb, M.D.

This is information the dairy industry does not want you to see. There are several articles that will intrigue you. The first is: The Effects of Commercial whole Milk on the Prostate Carcinogenesis in Rats with or without Induction by 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. These rats are used because their prostates behave similar to human prostates. This article will confirm that: Characterization of the Dunning R3327H prostatic adenocarcinoma: an appropriate animal model for prostatic cancer. The processes are likely similar for breast cancer,ovarian cancer and leukemia/non-Hodgkin's lymphoma. The government refuses to look into this danger. Please pass this information on to others in your e-mail list or facebook. Thank you.-R.Bibb